|
KMID : 0368820070460030254
|
|
Journal of the Korean Neuropsychiatr Association
2007 Volume.46 No. 3 p.254 ~ p.261
|
|
|
Correlation between Head Circumference and Cognition in the Elderly by ApoE Genotype
|
|
Kim Kyung-Ran
Oh Byoung-Hoon
Lee Jun-Young
Kim Eun-A
Cheong Hae-Kwan
Lee Dong-Woo
Hong Chang-Hyung
|
|
|
Abstract
|
|
|
Objectives: The aim of this study is to find out the effect of ApoE genotype on correlation between head circumference and cognition of the elderly in the community.
Methods: A total of 1,152 subjects (380 men and 772 women) aged 60-91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history and K-MMSE (Korean version-Mini Mental State Examination). We also measured the head circumference and examined ApoE genotype.
Results: On regression analysis, as head circumference becomes smaller, K-MMSE scores decreased adjusted by age, sex, educational level, ApoE epsilon4 allele, current smoking and alcohol drinking status (beta=0.15, p=0.04). Only in the lowest quartile group, presence of ApoE epsilon4 allele reduced K-MMSE scores adjusted by age, sex, educational level, height, current alcohol drinking and smoking status (beta=-1.39, p=0.008).
Conclusion: These results suggest that head circumference may have an influence on K-MMSE scores, and presence of ApoE epsilon4 allele may be a medicating factor.
|
|
|
KEYWORD
|
|
|
Head circumference, Cognition, K-MMSE, Eldery, ApoE genotype, Brain reserve
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|